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M94A0575.TXT
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1994-10-21
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Document 0575
DOCN M94A0575
TI In vitro studies of Schwann cell infectivity by human immunodeficiency
virus (HIV).
DT 9412
AU Ayers MM; Turnbull V; Siregar H; Crowe SM; Gonzales MF; Neuropathology
Research Laboratory, Royal Melbourne Hospital,; Parkville, Vic.
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:99 (poster no. 48).
Unique Identifier : AIDSLINE ASHM5/94349080
AB Attention has recently focussed on Schwann cells as antigen presenting
cells in inflammatory demyelinating polyneuropathy (IDPN). Whether
Schwann cells process and present antigen following viral infection is
of particular interest. To determine if human Schwann cells can be
infected by HIV, cultures of Schwann cells were established from a sural
nerve biopsy in a patient with Type 1 hereditary motor sensory
neuropathy (HMSN). Three cultures were established over a period of
eight weeks. Two cultures were then exposed to the Ba-L strain of HIV.
HIV p24 was quantified in all three culture supernatants by ELISA and
cultures double immunostained for p24 and the Schwann cell marker, S-100
protein. The data from these experiments are preliminary but indicate
that Schwann cells can be infected in vitro by HIV. Infection of Schwann
cells by HIV may be an important event in the pathogenesis of
HIV-associated peripheral neuropathy.
DE Antigen-Presenting Cells/*IMMUNOLOGY Biopsy Cells, Cultured Human
HIV/*PATHOGENICITY HIV Infections/*IMMUNOLOGY Neuropathies, Hereditary
Motor and Sensory/PATHOLOGY Polyradiculoneuritis/*IMMUNOLOGY Schwann
Cells/*IMMUNOLOGY/MICROBIOLOGY Sural Nerve/IMMUNOLOGY/PATHOLOGY
Virulence MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).